Validating the assessment of glucose 6 phosphate dehydrogenase g6pd

Heinz bodies are also seen in patients with unstable forms of hemoglobin, such as hemoglobin Köln.

Heat stability and/or heat denaturation and high-performance liquid chromatography can be used to identify unstable hemoglobin and thereby rule out G6PD deficiency.

Abdominal ultrasound may be useful in assessing for splenomegaly and gallstones.

These complications are typically limited to patients with severe chronic hemolysis.

G-6-PD of blood erythrocytes is of particular interest because a decrease in its activity can lead to the condition called enzyme that catalyzes the reversible reaction of glutamic acid into 2-oxoglutaric acid and ammonia.

High concentrations occur in the liver of sheep, cattle, horses and dogs.

They also discuss the pathobiology of bilirubin-induced neurotoxicity, the clinical diagnosis and outcome of kernicterus, the contributions of hemolytic disease and glucose-6-phosphate dehydrogenase deficiency to hyperbilirubinemia, and risk assessment and treatment with phototherapy and other modalities.

set P("GENE,88475, GENE,312828, GENE,87719, CH,5073, CH,5075, ACTION_VERB,36, Me SH,45", "[)}\" Glucose-6-phosphate dehydrogenase\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"hlog\",\"G6PD\",\"z\",\"9\",\"|\", \"GENE\",312828,\"rz\",\"1\",\"org_name\",\"Bos taurus\",\"org_id\",\"383\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"hlog\",\"G6PD\",\"z\",\"9\",\"|\"[(} ([)}\" G-6-PDH\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"hlog\",\"G6PD\",\"z\",\"9\",\"|\", \"GENE\",312828,\"rz\",\"1\",\"org_name\",\"Bos taurus\",\"org_id\",\"383\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"hlog\",\"G6PD\",\"z\",\"9\",\"|\"[(}) inhibition partially [)}\" blocked\", \"ACTION_VERB\",36,\"q\",\"1\",\"class\",\"regulatory\",\"infinitive\",\"block\",\"cpos1\",\"1\",\"cpos2\",\"11\",\"|\"[(} [)}\" NQO1\", \"GENE\",87719,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"NQO1\",\"name\",\"NAD(P)H dehydrogenase, quinone 1\",\"z\",\"6\",\"|\"[(} activity in control and sulf-treated cells, but [)}\" G-6-PDH\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"hlog\",\"G6PD\",\"z\",\"9\",\"|\", \"GENE\",312828,\"rz\",\"1\",\"org_name\",\"Bos taurus\",\"org_id\",\"383\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"hlog\",\"G6PD\",\"z\",\"9\",\"|\"[(} overexpression via transient [)}\" transfection\", \"Me SH\",45,\"nr\",\"E.5.393.350.810\",\"name\",\"Transfection\",\"|\"[(} with the human c DNA alleviated neither the restriction on intact sulf-treated cell [)}\" NQO1\", \"GENE\",87719,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"NQO1\",\"name\",\"NAD(P)H dehydrogenase, quinone 1\",\"z\",\"6\",\"|\"[(} activity nor the impact on the [)}\" NADPH\", \"CH\",5073,\"name\",\"NADPH\",\"CID\",\"5884\",\"|\"[(}/[)}\" NADP\", \"CH\",5075,\"name\",\"NADP\",\"CID\",\"5886\",\"|\"[(}( ) ratios.", 15726235, 5, "21238579", 0.0, 2011); set P("GENE,88475, Me SH,1402, Me SH,9211", "His peripheral smear demonstrated \"blister cells,\" [)}\" erythrocytes\", \"Me SH\",1402,\"nr\",\"A11.118.290\",\"name\",\"Erythrocytes\",\"|\"[(} that have been left devoid of precipitated hemoglobin by the spleen, which are commonly seen in patients with [)}\" G6PD deficiency\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"7\",\"|\", \"Me SH\",9211,\"nr\",\"C16.320.070.480\",\"name\",\"Glucosephosphate Dehydrogenase Deficiency\",\"|\"[(}.", 16137163, 8, "21336800", 0.0, 2011); set P("GENE,88475, Me SH,9211, Me SH,2047", "DISCUSSION: Life-threatening intravascular [)}\" hemolysis\", \"Me SH\",2047,\"nr\",\"C23.550.403\",\"name\",\"Hemolysis\",\"|\"[(} may occur following a naturopathic vitamin infusion and may identify previously unknown [)}\" G6PD deficiency\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"7\",\"|\", \"Me SH\",9211,\"nr\",\"C16.320.070.480\",\"name\",\"Glucosephosphate Dehydrogenase Deficiency\",\"|\"[(}.", 16137163, 12, "21336800", 0.0, 2011); set P("GENE,88475, Me SH,9211, Me SH,8580", "Chronic nonspherocytic [)}\" hemolytic anemia\", \"Me SH\",8580,\"nr\",\"C.15.3\",\"name\",\"Anemia, Hemolytic\",\"|\"[(} (CNSHA) due to [)}\" G6PD deficiency\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"5\",\"|\", \"Me SH\",9211,\"nr\",\"C.15.3.150.480\",\"name\",\"Glucosephosphate Dehydrogenase Deficiency\",\"|\"[(} is rare.", 15994463, 4, "21302115", 0.0, 2011); set P("GENE,88475, Me SH,9211, Me SH,1271", "Introduction: The [)}\" glucose-6-phosphate dehydrogenase\", \"GENE\",88475,\"rz\",\"0\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"0\",\"|\"[(} ([)}\" G6PD\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"5\",\"|\"[(}) fluorescent spot test (FST) is a useful screening test for [)}\" G6PD deficiency\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"5\",\"|\", \"Me SH\",9211,\"nr\",\"C16.320.070.480\",\"name\",\"Glucosephosphate Dehydrogenase Deficiency\",\"|\"[(}, but is unable to detect [)}\" heterozygote\", \"Me SH\",1271,\"nr\",\"G05.380.383\",\"name\",\"Heterozygote\",\"|\"[(} [)}\" G6PD\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"5\",\"|\"[(}-deficient females.", 16184852, 2, "21501392", 0.0, 2011); set P("GENE,88475, Me SH,9211, Me SH,4438, Me SH,27120", "Methods: A total of 1266 [)}\" cord blood\", \"Me SH\",4438,\"nr\",\"A15.145.300\",\"name\",\"Fetal Blood\",\"|\"[(} samples (705 male, 561 female) were screened for [)}\" G6PD deficiency\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"5\",\"|\", \"Me SH\",9211,\"nr\",\"C16.320.070.480\",\"name\",\"Glucosephosphate Dehydrogenase Deficiency\",\"|\"[(} using FST (in-house method) and a quantitative [)}\" enzyme assay\", \"Me SH\",27120,\"nr\",\"E05.196.427\",\"name\",\"Enzyme Assays\",\"|\"[(}.", 16184852, 4, "21501392", 0.0, 2011); set P("GENE,88475, Me SH,1734, Me SH,9211", "The [)}\" methemoglobinemia\", \"Me SH\",1734,\"nr\",\"C.15.378.619\",\"name\",\"Methemoglobinemia\",\"|\"[(} revealed a previously unrecognized [)}\" glucose-6-phosphate dehydrogenase\", \"GENE\",88475,\"rz\",\"0\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"0\",\"|\"[(} [)}\" (G6PD) deficiency\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"5\",\"|\", \"Me SH\",9211,\"nr\",\"C.15.3.150.480\",\"name\",\"Glucosephosphate Dehydrogenase Deficiency\",\"|\"[(}.", 15893306, 3, "21479984", 0.0, 2011); set P("GENE,88475, CH,96333, Me SH,9211", "In an attempt to separate the antimalarial activity of [)}\" tafenoquine\", \"CH\",96333,\"name\",\"Tafenoquine\",\"CID\",\"115358\",\"|\"[(} (3) from its hemolytic side effects in [)}\" glucose-6-phosphate dehydrogenase\", \"GENE\",88475,\"rz\",\"0\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"0\",\"|\"[(} [)}\" (G6PD) deficiency\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"7\",\"|\", \"Me SH\",9211,\"nr\",\"C16.320.070.480\",\"name\",\"Glucosephosphate Dehydrogenase Deficiency\",\"|\"[(} patients, a series of 5-aryl-8-aminoquinoline derivatives was prepared and assessed for antimalarial activities.", 16223581, 2, "21141892", 0.0, 2011); set P("GENE,88475, Me SH,9211, Me SH,5689", "In our knowledge, this is the first report of favism-caused [)}\" syncope\", \"Me SH\",5689,\"nr\",\"C.23.888.592.604.359.800.600\",\"name\",\"Syncope\",\"|\"[(} in an adult patient without a [)}\" G6PD deficiency\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"6\",\"|\", \"Me SH\",9211,\"nr\",\"C.15.3.150.480\",\"name\",\"Glucosephosphate Dehydrogenase Deficiency\",\"|\"[(} diagnosis in the past and diagnosed in ED.", 15761202, 5, "20930025", 0.0, 2011); set P("GENE,88475, Me SH,9211, Me SH,5835", "We sought to learn in which direction [)}\" G6PD deficiency\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"5\",\"|\", \"Me SH\",9211,\"nr\",\"C.15.3.150.480\",\"name\",\"Glucosephosphate Dehydrogenase Deficiency\",\"|\"[(} affects [)}\" diabetic retinopathy\", \"Me SH\",5835,\"nr\",\"C.19.2.382\",\"name\",\"Diabetic Retinopathy\",\"|\"[(}.", 15855344, 5, "21380594", 0.0, 2011); set P("GENE,88475, CH,11261198, Me SH,14229, Me SH,9211", "Conversely, [)}\" G6PD deficiency\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"5\",\"|\", \"Me SH\",9211,\"nr\",\"C.15.3.150.480\",\"name\",\"Glucosephosphate Dehydrogenase Deficiency\",\"|\"[(} can promote [)}\" oxidative stress\", \"Me SH\",14229,\"nr\",\"G.7.700.830.750\",\"name\",\"Oxidative Stress\",\"|\"[(} and impairment of [)}\" insulin\", \"CH\",11261198,\"name\",\"Insulin\",\"CID\",\"16129672\",\"|\"[(} secretion by beta cells.", 15691731, 12, "21147013", 0.0, 2011); set P("GENE,88475, GENE,99993, Me SH,9211, Me SH,427, Me SH,4437", "CONCLUSION: Breast-fed [)}\" neonates\", \"Me SH\",427,\"nr\",\"M01.060.703.520\",\"name\",\"Infant, Newborn\",\"|\"[(} who are 211 variants in the [)}\" UGT1A1\", \"GENE\",99993,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"UGT1A1\",\"name\",\"UDP glucuronosyltransferase 1 family,...\",\"z\",\"36\",\"|\"[(}, [)}\" G6PD deficiency\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"36\",\"|\", \"Me SH\",9211,\"nr\",\"C16.320.070.480\",\"name\",\"Glucosephosphate Dehydrogenase Deficiency\",\"|\"[(}, and vaginal delivery are at high-risk for [)}\" hyperbilirubinemia\", \"Me SH\",4437,\"nr\",\"C23.550.429\",\"name\",\"Hyperbilirubinemia\",\"|\"[(}.", 16229861, 8, "21592495", 0.0, 2011); set P("GENE,88475, Me SH,9211, Me SH,1271, Me SH,551", "Distinguishing samples with intermediate [)}\" fluorescence\", \"Me SH\",551,\"nr\",\"G01.590.540.665.500\",\"name\",\"Fluorescence\",\"|\"[(} from absent and bright [)}\" fluorescence\", \"Me SH\",551,\"nr\",\"G01.590.540.665.500\",\"name\",\"Fluorescence\",\"|\"[(} improves detection of [)}\" heterozygote\", \"Me SH\",1271,\"nr\",\"G05.380.383\",\"name\",\"Heterozygote\",\"|\"[(} females with mild [)}\" G6PD deficiency\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"5\",\"|\", \"Me SH\",9211,\"nr\",\"C16.320.070.480\",\"name\",\"Glucosephosphate Dehydrogenase Deficiency\",\"|\"[(}.", 16184852, 14, "21501392", 0.0, 2011); set P("GENE,88475, GENE,99993, CH,113997, Me SH,334, Me SH,9211", "The significant [)}\" risk factors\", \"Me SH\",334,\"nr\",\"N05.715.350.200.700\",\"name\",\"Risk Factors\",\"|\"[(} were a variant nucleotide 211 in [)}\" UGT1A1\", \"GENE\",99993,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"UGT1A1\",\"name\",\"UDP glucuronosyltransferase 1 family,...\",\"z\",\"36\",\"|\"[(} (2.48; 95% CI, 1.29 to 4.76; [)}\" P\", \"CH\",113997,\"name\",\"Phosphino\",\"CID\",\"139579\",\"|\"[(} = .006), [)}\" G6PD deficiency\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"36\",\"|\", \"Me SH\",9211,\"nr\",\"C16.320.070.480\",\"name\",\"Glucosephosphate Dehydrogenase Deficiency\",\"|\"[(} (12.24; 95% CI, 1.08 to 138.62; [)}\" P\", \"CH\",113997,\"name\",\"Phosphino\",\"CID\",\"139579\",\"|\"[(} [)}\" T\", \"CH\",4173073,\"name\",\"Triton\",\"CID\",\"5460632\",\"|\", \"CH\",4173074,\"name\",\"monotritium\",\"CID\",\"5460633\",\"|\", \"CH\",4916944,\"name\",\"tritide\",\"CID\",\"6857427\",\"|\"[(}), which is a common variant in the Chinese population.", 15096552, 9, "20200584", 0.753, 2010); set P("GENE,88475, CH,122278, Me SH,7370, Me SH,10347, Me SH,1943, Me SH,4905, Me SH,6937", "[)}\" Birth control\", \"Me SH\",7370,\"nr\",\"E.2.875.194\",\"name\",\"Contraception\",\"|\"[(} necessary to limit [)}\" family size\", \"Me SH\",10347,\"nr\",\"N.6.850.505.400.400\",\"name\",\"Family Characteristics\",\"|\"[(} in tribal couples with aberrant [)}\" heterosis\", \"Me SH\",6937,\"nr\",\"G.5.400\",\"name\",\"Hybrid Vigor\",\"|\"[(} of [)}\" G-6-PD\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"12\",\"|\"[(} deficiency and [)}\" sickle cell disorders\", \"Me SH\",4905,\"nr\",\"C.15.3.150.150\",\"name\",\"Anemia, Sickle Cell\",\"|\"[(} in [)}\" India\", \"CH\",122278,\"name\",\"India\",\"CID\",\"150905\",\"|\"[(}: an urgency of creating awareness and imparting [)}\" genetic counseling\", \"Me SH\",1943,\"nr\",\"H.1.158.273.343.315.384\",\"name\",\"Genetic Counseling\",\"|\"[(}.", 15533598, 1, "21125776", 0.0, 2010); set P("GENE,88475, CH,349970, Me SH,157", "The frequencies of the common polymorphism site C1311T/[)}\" IVS\", \"CH\",349970,\"name\",\"CHEMBL433050\",\"CID\",\"444340\",\"|\"[(} ([)}\" intervening sequence\", \"Me SH\",157,\"nr\",\"G.5.360.3.137.515\",\"name\",\"Introns\",\"|\"[(}) XI t93c between patients with [)}\" G6PD\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"17\",\"|\"[(} and healthy volunteers were not significantly different.", 15073203, 10, "20203002", 0.0, 2010); set P("GENE,88475, Me SH,9278, Me SH,14495", "Derangement in the nitric oxide (NO) pathway, which can occur in both [)}\" Fabry disease\", \"Me SH\",9278,\"nr\",\"C.10.228.140.163.100.435.825.200\",\"name\",\"Fabry Disease\",\"|\"[(} and [)}\" G6PD\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"8\",\"|\"[(}, is suggested as a hypothesis for the [)}\" priapism\", \"Me SH\",14495,\"nr\",\"C.12.294.494.786\",\"name\",\"Priapism\",\"|\"[(} in our patients.", 15122868, 7, "20102445", 0.0, 2010); set P("GENE,88475, Me SH,9278, Me SH,3808, Me SH,14495", "[)}\" Fabry disease\", \"Me SH\",9278,\"nr\",\"C.10.228.140.163.100.435.825.200\",\"name\",\"Fabry Disease\",\"|\"[(} and [)}\" G6PD\", \"GENE\",88475,\"rz\",\"1\",\"org_name\",\"Homo sapiens\",\"org_id\",\"1\",\"symbol\",\"G6PD\",\"name\",\"glucose-6-phosphate dehydrogenase\",\"z\",\"8\",\"|\"[(} in three [)}\" family members\", \"Me SH\",3808,\"nr\",\"F.1.829.263\",\"name\",\"Family\",\"|\"[(} with [)}\" priapism\", \"Me SH\",14495,\"nr\",\"C.12.294.494.786\",\"name\",\"Priapism\",\"|\"[(}: is the nitric oxide pathway to blame?Also, spectrophotometric quantitation may fail to detect deficiency in heterozygous females due to residual activity in G6PD-sufficient cells.The identification of G6PD-deficient as well as G6PD-sufficient cells by a cytochemical method or cytofluorometry is more sensitive in the testing for G6PD deficiency in females.It appears in elevated concentrations when these tissues are injured.-glucono-δ-lactone, this reaction initiating the pentose shunt.A deficiency of this enzyme can lead to severe hemolytic anemia and favism.Serum levels have been used to detect hepatocellular damage, but it is not highly enzyme that catalyzes the interconversion of lactate and pyruvate.

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