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Common infection of the skin or mucosa may affect the face and mouth (orofacial herpes), genitalia (genital herpes), or hands (herpetic whitlow).

More serious disorders occur when the virus infects and damages the eye (herpes keratitis), or invades the central nervous system, damaging the brain (herpes encephalitis).

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Individuals who participate in contact sports such as wrestling, rugby, and football(soccer), sometimes acquire a condition caused by HSV-1 known as herpes gladiatorum, scrumpox, wrestler's herpes, or mat herpes, which presents as skin ulceration on the face, ears, and neck.

Symptoms include fever, headache, sore throat, and swollen glands. A herpetic infection of the brain thought to be caused by the transmission of virus from a peripheral site on the face following HSV-1 reactivation, along the trigeminal nerve axon, to the brain.

HIV/AIDS, immunosuppression in solid organ transplants). Neonatal herpes simplex is a HSV infection in an infant.

It is a rare but serious condition, usually caused by vertical transmission of HSV-1 or -2) from mother to newborn.

Infections are categorized based on the part of the body infected. It may result in small blisters in groups often called cold sores or fever blisters or may just cause a sore throat.

Herpes simplex is divided into two types; HSV-1 causes primarily mouth, throat, face, eye, and central nervous system infections, whereas HSV-2 causes primarily anogenital infections. HSV infection causes several distinct medical disorders.

HSV is the most common cause of viral encephalitis.

When infecting the brain, the virus shows a preference for the temporal lobe.

The appearance and distribution of sores in these individuals typically presents as multiple, round, superficial oral ulcers, accompanied by acute gingivitis.

Adults with atypical presentation are more difficult to diagnose.

Herpes simplex virus 2 is typically contracted through direct skin-to-skin contact with an infected individual, but can also be contracted by exposure to infected saliva, semen, vaginal fluid, or the fluid from herpetic blisters.

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